Program

16thbis International Wolfsberg Meeting on

Molecular Radiation Biology/Oncology

Hurdalsjøen Hotel, Norway

June 17-19, 2023

Organizers:

Ludwig Dubois (NL)

Heidi Lyng (NO)

Martin Pruschy (CH)

Randi Syljuåsen (NO)

15:00

Opening and Welcome Address

Ludwig Dubois (NL, Maastricht), Heidi Lyng (NO, Oslo), Martin Pruschy (CH, Zurich) & Randi Syljuåsen (NO, Oslo)

15:15 - 16:15

Opening Keynote Lecture

Chairs: Randi Syljuåsen & Bhawna Singh

Scott Lowe, New York, USA
Understanding and exploiting tumor suppressor gene networks

Session 1

Topic 1: DNA repair

Chairs: Randi Syljuåsen & Bhawna Singh

16:15 - 16:45

Invited Lecture

Alessandro A. Sartori, Zurich, CH
Targeting DSB repair in cancer: Hopes and Pitfalls

16:45 - 18:45

Coffe break /

Poster Session Topic 1 (Poster numbers PI.1-PI.20)

18:45 - 19:45

Proffered Paper Talks

18:45 - 19:05

Marcel van Vugt, Groningen, NL

Determinants of inflammatory signaling in genomically instable cancers

19:05 - 19:25

Helga B. Landsverk, Oslo, NO

The RNA polymerase II C-terminal domain promotes non-homologous end-joining

19:25 - 19:45

Sunil J Advani, San Diego, US

Spatially precise radio-chemo-immunotherapy using antibody drug conjugate targeted radiosensitizers

20:00

Wolfsberg Barbecue and Late night swimming

Session

Topic 2: Intra- and Intercellular Signaling

Chairs: Martin Pruschy & Davide Sinat

08:00-08:30

Invited Lecture 1

Sonia Rocha, Liverpool, UK

Molecular oxygen is a potent signaling molecule, lessons from chromatin analysis

08:30-09:00

Invited Lecture 2

Claus Sørensen, Copenhagen, DK

Self-inflicted DNA breaks allow cancer cell escape from growth limits imposed by genotoxic stress

09:00-11:00

Coffee Break / Poster Session Topic II (Poster numbers PII.1-PII.28)

11:00-12:00

Proffered Paper Talks

11:00 - 11:20

Charles Fouillade, Paris, FR

An interactive single cell atlas of the lung responses to radiation injury

11.20 - 11:40

Florian Wisdorfer, Essen, GE

The role of Neuropilin-1 as therapeutic target in radiation-induced lung fibrosis

11:40 - 12:00

Gosse Adema, Nijmegen, NL

cGAS localization and activation: a guide towards effective combination of RT and Immunotherapy?

12:15 - 13:15

Lunch

Session 2

Topic 3: Microenvironment

Chairs: Ludwig Dubois & Hala Awada

13:30-14:00

Invited Lecture 1

Ester Hammond, Oxford, UK

Hypoxia-induced ROS contribute to both replication and transcriptional stress independently of DNA damage

14:00-14:30

Invited Lecture 2

Arne Östmann, Stockholm, SE

Novel subsets of cancer-associated fibroblasts linked to prognosis, response to treatment and immune surveillance

14:30-16:30

Coffee Break / Poster Session Topic III (Poster numbers PIII.1-PIII.24)

16:30-17:30

Proffered Paper Talks

16:30-16:50

Irma Telarovic, Zurich, CH

Delayed tumor draining lymph node irradiation to maximize the treatment benefit of radiotherapy - immunotherapy

16:50 - 17:10

Sandeep Burma, San Antonio, US

Radiation-induced senescence as a driver of glioblastoma recurrence

17:10 - 17:30

Marianne Koritzinsky, Toronto, CA

Targeting redox homeostasis to reprogram the tumor microenvironment in pancreatic cancer

18:30 - 19:30

WOslo Cup

20:00

WOslo Dinner

Session 4

Topic 4: Novel Therapies and Biomarkers

Chairs: Heidi Lyng & Kateryna Onyshchenko

08:00 - 08:30

Invited Lecture 1

Fernanda Herrera, Lausanne, CH

Overcoming immune resistance with radiation therapy

8:30-9:00

Invited Lecture 2

Pierre Montay-Gruel, Antwerp, BE

FLASH Radiotherapy: a radiobiology point of view on the FLASH effect

09:00-11:00

Coffee Break / Poster Session Topic IV (Poster numbers PIV.1-PIV.27)

11:00-12:00

Proffered Paper Talks

11:00-11:20

Ala Yaromina, Maastricht, NL

Impact of LET on tumor response in vivo: potential cooperativity with immunotherapy

11:20-11:40

Randall Kimple, Wisconsin, US

First in human study of autologous MSC(M) for the treatment of radiation-induced xerostomia

11:40-12:00

Mechthild Krause, Dresden, GE

Biomarkers for radio(chemo)therapy in patient HNSCC and in xenografts are similar: clinical validation

12:00-12:25

Award Ceremony

Wolfsberg Poster Awards

12:25-12:30

Closing Remarks

12:30-13:15

Lunch

13:30

Bus Departure to Oslo Airport